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The Next Generation of Wrinkle Relaxers: Longer-Lasting, Peptide-Enhanced Smoothness

Our licensed nurse injectors and aesthetic specialists perform every injectable treatment with the same standard of excellence that defines our AAAHC-accredited practice. DAXXIFY® represents a significant advancement in neuromodulator science, offering long-lasting wrinkle reduction powered by proprietary peptide technology. Each treatment is personalized to your anatomy and goals, ensuring results that look natural and feel authentically you.

What Is DAXXIFY®?

DAXXIFY® (daxibotulinumtoxinA-lanm) is an FDA-approved injectable treatment that temporarily improves the appearance of moderate to severe frown lines (glabellar lines) by relaxing overactive facial muscles (FDA label, 2022).

Like other neuromodulators, it works by blocking the release of acetylcholine at the neuromuscular junction, reducing muscle contraction and softening dynamic wrinkles (MedlinePlus).

What distinguishes DAXXIFY® is its stabilizing peptide exchange technology, which replaces human serum albumin used in other formulations. This allows the active ingredient to remain effective for a longer period and minimizes exposure to animal- or human-derived additives (Overview of DaxibotulinumtoxinA for Injection: A Novel Formulation of Botulinum Toxin Type A).

DAXXIFY® Benefits

Additional benefits include the following:

  • Predictable, consistent performance: Patients often notice a steadier fade pattern between treatments, supporting easier long-term maintenance.
  • Refined control for facial balance: Precise placement can soften expression lines while preserving your natural movement and emotional expressiveness.
  • Albumin-free formulation: An alternative for patients who prefer or require treatments free of human or animal proteins.
  • Compatible with comprehensive rejuvenation plans: May be safely combined with fillers, laser resurfacing, or skincare programs as part of a holistic maintenance strategy under the guidance of a professional.
  • Confidence in a modern, FDA-approved therapy: Backed by rigorous clinical evaluation and safety monitoring standards.

DAXXIFY® was developed to enhance both patient experience and treatment flexibility. Its unique formulation allows your provider to design personalized plans that fit your aesthetic rhythm.

Are You a Candidate?

You may be a candidate for DAXXIFY if you:

  • Have moderate to severe frown lines or dynamic wrinkles caused by repetitive facial motion
  • Desire longer-lasting wrinkle reduction with fewer maintenance treatments per year
  • Prefer a vegan-friendly, albumin-free injectable formulation
  • Want refreshed, natural-looking results without a “frozen” appearance
  • Are in good general health, with no active skin infections, inflammation, or lesions at the planned injection sites
  • Do not have neuromuscular disorders such as myasthenia gravis, Lambert-Eaton syndrome, or amyotrophic lateral sclerosis (ALS)
  • Are not pregnant or breastfeeding, as safety has not been established for these populations
  • Are not allergic to botulinum toxin or any of its components

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What to Expect Before, During, and After Treatment

Consultation

Your provider will review your medical history and aesthetic goals, explain the available options, and tailor a plan to achieve optimal facial balance.

Treatment

Each DAXXIFY® session takes only minutes. A very fine needle is used to deliver precise, comfortable injections—no anesthesia or downtime required.

Recovery and Results

You may notice an initial improvement within two to three days, with full results typically appearing in one to two weeks. Aftercare is straightforward: avoid rubbing the area, remain upright for several hours, and limit alcohol and NSAIDs for a day to minimize minor bruising. Results typically last six to nine months, varying by individual muscle activity and metabolism.

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Toxin Comparison Chart

Product Active Ingredient Typical Duration Distinguishing Feature Additives Primary Indication
BOTOX® OnabotulinumtoxinA ~3–4 months Widely studied standard neuromodulator Contains human albumin Forehead, crow’s feet, glabellar lines
Dysport® AbobotulinumtoxinA ~3–4 months Broader diffusion; faster onset Contains human albumin Glabellar lines
Xeomin® IncobotulinumtoxinA ~3–4 months “Naked” toxin, no complexing proteins Contains human albumin Forehead, crow’s feet
DAXXIFY® DaxibotulinumtoxinA-lanm ~6–9 months Peptide-stabilized for extended duration No human or animal additives Glabellar lines

Why Choose Rousso Adams Facial Plastic Surgery?

Every injectable treatment at Rousso Adams is performed by highly trained nurse injectors and aesthetic specialists under the guidance of our board-certified facial plastic surgeons, within our AAAHC-accredited facility. Patients throughout Birmingham and beyond choose our team for artistry, safety, and natural-looking rejuvenation.

Our focus is on facial balance and patient comfort, helping you look refreshed but completely yourself.

FAQ

How is DAXXIFY® different from traditional neuromodulators like BOTOX®?

While both are type A botulinum toxin products, DAXXIFY® uses a novel peptide-exchange stabilizer instead of human serum albumin. This formulation helps the active ingredient remain stable and effective for a longer period, often extending results to six months or more in many patients.

What areas can DAXXIFY® treat?

The FDA approved DAXXIFY® for glabellar (frown) lines between the eyebrows. However, trained injectors may also use it off-label for other dynamic lines such as forehead creases and crow’s feet, depending on facial anatomy and safety considerations.

How long does a DAXXIFY® appointment take?

Most sessions last between 10 and 20 minutes. After a brief consultation and preparation, your injector performs a series of small, precise injections. Patients typically resume normal activities immediately afterward.

How soon will I see results?

Improvement can appear within two to three days, with optimal smoothing at one to two weeks post-treatment. The gradual onset allows your skin and muscle tone to adjust naturally, avoiding an abrupt or “frozen” change in appearance.

How often will I need maintenance treatments?

Because of its peptide-enhanced stability, DAXXIFY® may maintain results for six to nine months—nearly twice the longevity of conventional neuromodulators. Your injector will help schedule follow-ups based on your muscle activity and personal goals.

What are the possible risks or side effects of DAXXIFY®?

Most side effects are mild and temporary, such as localized redness, swelling, or tenderness at injection sites. Less common effects include temporary eyelid or brow droop, headache, or asymmetry, which typically resolve within a few days to a few weeks. Serious adverse events are rare but may include muscle weakness or an allergic reaction if the toxin spreads beyond the injection site. Your injector will review all safety details during your consultation to ensure you are an appropriate candidate.

Will DAXXIFY® affect how my face moves or feels?

When administered precisely, DAXXIFY® softens targeted muscle activity while preserving natural facial expression. You’ll continue to look animated and approachable—simply smoother and more rested.

How do I choose the right injector for DAXXIFY®?

Safety and outcomes depend heavily on training, technique, and anatomical knowledge. At Rousso Adams Facial Plastic Surgery, all DAXXIFY® treatments are performed by licensed nurse injectors and aesthetic specialists under the guidance of our facial plastic surgeons, within an AAAHC-accredited facility. This ensures precision, safety, and results that are balanced, beautiful, and natural.

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